克罗米酚对男同性恋低促性腺素性功能减退症有效

纽约（CNN健康国际版）1月末四日报道：据发表在12月末出国际版的《不孕与不育》时代周刊的一项通报指出克罗米醇对大部分低促性腺素性功用减退的成年人病患十分困难。来自伯明翰阿拉巴马大学的该通报的第一编者Scott J. Whitten博士在接受德意志银行通讯社采访谈起：“上皮细胞或获得性HH病患在接受侵害性相当大和更为昂贵的治疗法（例如注射促性腺激素类）从前透过4个月末的克罗米醇了了治疗法是十分困难的。”Whitten博士和同事分析了克罗米醇对10名HH成年人病患（HH是导致成年人不育的少见各种因素）前提有效。通报援引克罗米醇治疗法1年后，4名卡尔曼(氏)syndrome病患中只有一名病患的卵子含量增加而全小脑功用减退症病患的卵子依赖症状均不会得到改善。也就是话说，该通报指出3名成年发病的上皮细胞HH成年人病患经过3个月末克罗米醇的治疗法卵子含量有了明显增加。目从前为止该组病患早两名恢复原了不孕。Whitten博士话说：“除非对克罗米醇治疗法不会反应，我们不会因为副作用中断对病患采用该本品。”先前编者总结话说：“因为先决条件有限，对HH病患促性腺激素类本品和克罗米醇的随机分析不足以透过，然而借助于多复刻国际版的宽松选择标准对病患透过分级制度可能希望全面性验证克罗米醇恢复原成年人低不孕的正确性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：深蓝色梦幻

编辑： 张靖